Cannabis and the treatment of epilepsy
Epilepsy affects 1.5% of the world population. A third of this population suffers from what is known as refractory or refractory epilepsy, that is, it does not respond to conventional treatments.
It is common for patients suffering from refractory epilepsy to have unsuccessfully experienced several seizure control attempts with different medications (3 to 5 or more antiepileptic drugs and steroids), as well as other treatments such as the ketogenic diet, vagal stimulation, and even surgery. Likewise, they frequently suffer from the side effects of these treatments that add to the damage of the underlying disease. Dank vapes for sale
This means that a significant percentage of patients with epilepsy do not have a satisfactory therapeutic response, with those suffering from dozens and even hundreds of daily attacks. Many of these cases do not reach adulthood.
In the history of medicine, it is possible to find records on the use of cannabis in the treatment of seizures, one of the clinical forms of epileptic seizures, long before the Christian era. Marijuana marketing online
In our time, the use of cannabis, and particularly cannabidiol (CBD) in the treatment of epilepsy, has been spreading based on the findings of preclinical and clinical research, as well as multiple accounts of significant improvements in different types of epilepsy of difficult control not classified and in the context of syndromes such as Dravet, Lennox-Gastaut, Doose, and West. Buy cannabis oil online
Anticonvulsant action of CBD in the treatment of epilepsy
This effect of CBD was one of his first actions described by various researchers throughout the 70s and 80s.
The mechanism or mechanisms of action by which CBD could act are not fully understood and known, but it is known that in its present levels of anandamide, one of the endogenous cannabinoids, increase.
CBD interactions with other antiepileptic drugs
The interactions of CBD with other antiepileptic drugs should be taken into account since it can increase the effect of some, such as phenobarbital by inhibiting its destruction, and interfere with the effect of others such as chlordiazepoxide and ethosuximide. Consequently, attention should be paid to the appearance of adverse effects, which may be due more to the lack of inactivation of antiepileptic drugs than to CBD itself. This does not mean that CBD does not have undesirable effects, but they are mild to moderate and regress rapidly with dose adjustments or withdrawal of treatment. Buy Dank Vapes online
When the use of CBD is incorporated into the treatment of epilepsy, the conventional medication should not be discontinued abruptly, but doses should be lowered slowly and under medical supervision as improvement or adverse effects of drug accumulation occur.
Effects of CBD in the treatment of epilepsy
In patients on CBD treatment, associated or not with other antiepileptic drugs, in addition to the reduction of seizures by a significant percentage, generally greater than 50% until total cessation, an improvement is verified in other aspects such as, for example, emotional, cognitive and motor level, as well as in socialization. Buy Hemp Products
Finally, regarding cannabis and the treatment of epilepsy, there are some cases that do not respond satisfactorily. In these situations, it may be necessary to add THC, which must be done carefully, as it can alleviate or trigger seizures, a phenomenon that is usually dose-dependent. Marijuana online store